Pollard M, Luckert P H
Lobund Laboratory, University of Notre Dame, IN 46556.
Anticancer Res. 1993 May-Jun;13(3):705-8.
The complication of metastasis from the primary tumor site to the distant organ is difficult to control. Tumor cells usually spread through the vascular system: lymphatics and/or blood; or by direct extension into adjacent sites. Transplantable prostate adenocarcinoma (PA-III) cells in L-W rats produces a tumor in the implant site and then spreads via the ipsilateral lymphatic route to the lungs in which new visible tumors develop. Viable bacillus Calmette-Guerin (BCG) was inoculated SC or IV into rats which were then inoculated either SC or IV with PA-III cells. They were examined thereafter for primary and for lung tumors. IV-inoculated BCG generated a strong intravascular intervention mechanism on metastatic PA-III cells in L-W rats. This immobilization mechanism was not demonstrable in rats that had been inoculated SC with BCG.
