Pollard M, Luckert P H
Lobund Laboratory, University of Notre Dame, IN 46556.
Cancer Lett. 1991 Aug;59(2):159-63. doi: 10.1016/0304-3835(91)90181-g.
Tumor cells of transplanted prostate adenocarcinoma-III (PA-III) spread with very high frequency from the extravascular implant site through ipsilateral lymphatic channels to the lungs in which they produce visible focal tumors. The latter enlarge, coalesce and eventually kill the host. This system was used to demonstrate the effect of a retinoid on metastasis. Lobund-Wistar (L-W) rats were administered 1 mmol 4-HPR/kg diet L-485, and control rats received the same diet without 4-HPR. After an interval, all rats were inoculated subcutaneously with PA-III cells. When examined at autopsy, all rats had developed an anticipated tumor at the implant site. However, the numbers of focal PA-III tumors in the lungs were significantly reduced among the 4-HPR-treated rats compared to the control rats (P = 0.002).
移植性前列腺腺癌III型（PA-III）的肿瘤细胞以非常高的频率从血管外植入部位通过同侧淋巴通道扩散至肺部，并在肺部形成可见的局灶性肿瘤。这些肿瘤会不断增大、融合，最终导致宿主死亡。该系统被用于证明视黄酸对转移的影响。给Lobund-Wistar（L-W）大鼠喂食含1 mmol 4-HPR/kg的L-485饲料，对照大鼠则喂食不含4-HPR的相同饲料。经过一段时间后，所有大鼠均皮下接种PA-III细胞。尸检时发现，所有大鼠在植入部位均出现了预期的肿瘤。然而，与对照大鼠相比，接受4-HPR治疗的大鼠肺部的PA-III局灶性肿瘤数量显著减少（P = 0.002）。
