Pollard M
Lobund Laboratory, University of Notre Dame, IN 46556, USA.
Cancer Lett. 1996 Mar 19;101(1):21-4. doi: 10.1016/0304-3835(95)04105-2.
Two contradictory actions have been ascribed to thalidomide relative to tumor metastasis: immunosuppression and anti-angiogenesis. The latter effect was determined with basic fibroblast growth factor in a rabbit cornea micropocket assay system. The prostate adenocarcinoma (PA-III) transplanted tumor line in Lobund-Wistar (L-W) rats produces a tumor at the subcutaneous implant site from which tumor cells metastasize uniformly only through lymphatic channels through the heart to the lungs in which secondary tumors develop. L-W rats were implanted with PA-III cells and administered, by gavage, thalidomide (50 mg/kg body wt per day) in corn oil. Control rats with PA-III cells were administered corn oil. Autopsy examinations on day 30 revealed that the thalidomide-treated rats developed more metastatic tumor foci in the lungs than in the controls.
免疫抑制和抗血管生成。后者的作用是在兔角膜微袋试验系统中用碱性成纤维细胞生长因子测定的。洛本德-威斯塔（L-W）大鼠体内移植的前列腺腺癌（PA-III）肿瘤系在皮下植入部位形成肿瘤，肿瘤细胞仅通过淋巴管均匀地转移，经心脏至肺部，在肺部形成继发性肿瘤。给L-W大鼠植入PA-III细胞，并通过灌胃给予沙利度胺（每天50mg/kg体重）的玉米油溶液。植入PA-III细胞的对照大鼠给予玉米油。30天时的尸检显示，沙利度胺处理组大鼠肺部的转移瘤灶比对照组更多。
