乳腺癌中5号染色体长臂21区（APC/MCC）和18号染色体长臂21区（DCC）的等位基因缺失及DCC信使核糖核酸表达
Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer.
作者信息
Thompson A M, Morris R G, Wallace M, Wyllie A H, Steel C M, Carter D C
机构信息
University Department of Surgery, Royal Infirmary, Edinburgh, UK.
出版信息
Br J Cancer. 1993 Jul;68(1):64-8. doi: 10.1038/bjc.1993.287.
Thirty-four primary, untreated sporadic breast cancers were examined for loss of heterozygosity (LOH) at tumour suppressor loci involved in colorectal cancer: APC/MCC at 5q21 and DCC at 18q21. LOH was identified in 28% informative patients at 5q21 and 31% at 18q21. LOH at 5q21 and 18q21 was compared with allele loss at 17p13 and concurrent LOH at two or more of the loci was noted in 24% of tumours. Expression of a 12 kb DCC mRNA was demonstrated in 14/34 (42%) of the cancers and in all five tumours with LOH at the DCC locus there was an additional 11 kb DCC mRNA. Abnormalities of three loci involved in colorectal cancer (5q21, 17p13 and 18q21) therefore also occur in sporadic breast cancer. The accumulation of such genetic abnormalities may confer a growth advantage important in the development of breast cancer.
对34例原发性、未经治疗的散发性乳腺癌进行检测，以研究参与结直肠癌的肿瘤抑制基因座的杂合性缺失（LOH）情况：5q21处的APC/MCC和18q21处的DCC。在5q21处，28%的信息充足患者检测到LOH；在18q21处，31%的患者检测到LOH。将5q21和18q21处的LOH与17p13处的等位基因缺失进行比较，发现24%的肿瘤存在两个或更多位点的并发LOH。在14/34（42%）的癌症中检测到12 kb DCC mRNA的表达，在所有五个DCC基因座存在LOH的肿瘤中，还检测到11 kb DCC mRNA。因此，参与结直肠癌的三个基因座（5q21、17p13和18q21）的异常也出现在散发性乳腺癌中。这种遗传异常的积累可能赋予在乳腺癌发展中起重要作用的生长优势。
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