Abdulla E M, Campbell I C
Department of Neuroscience, Institute of Psychiatry, London, England, U.K.
J Pharmacol Toxicol Methods. 1993 Apr;29(2):69-75. doi: 10.1016/1056-8719(93)90053-h.
This review presents some of the newer techniques in the rapidly advancing area of neurotoxicity testing in vitro. They are not described at length, and more details can be obtained from the cited references. In vitro testing offers the possibility of relatively inexpensive screening of large numbers of pharmaceutical compounds, formulations, and environmental substances. The level of sophistication attained in this field may soon allow much more accurate safety limits to be set, as specific mechanisms of neurotoxicity are elucidated.
本综述介绍了体外神经毒性测试这一快速发展领域中的一些新技术。文中对这些技术的描述并不详尽，更多细节可从引用文献中获取。体外测试为大量药物化合物、制剂及环境物质的相对低成本筛选提供了可能。随着神经毒性具体机制的阐明，该领域所达到的复杂程度可能很快就能设定更为准确的安全限值。
