Inoue Y, Kondo N, Motoyoshi F, Inoue R, Orii T
Department of Pediatrics, Gifu University School of Medicine, Japan.
Acta Paediatr. 1993 Apr;82(4):404-7. doi: 10.1111/j.1651-2227.1993.tb12707.x.
Responses of common variable immunodeficiency patients' B cells to Staphylococcus aureus Cowan I (SAC) and recombinant interleukin-2 (rIL-2) varied in our study. T-cell function and IL-2 production were normal, and intrinsic B-cell defects were suggested. Some patients showed no increase in expression of IL-2 receptors on B cells with SAC stimulation, which may be due to impaired maturation stages. Two patients showed an increased level of B cells with IL-2 receptors, suggesting blocked development of intracellular mechanisms. One patient may have a defect in immunoglobulin isotype switching.
在我们的研究中，常见可变免疫缺陷患者的B细胞对金黄色葡萄球菌考恩I株（SAC）和重组白细胞介素-2（rIL-2）的反应各不相同。T细胞功能和IL-2产生正常，提示存在内在B细胞缺陷。一些患者在SAC刺激下B细胞上IL-2受体的表达没有增加，这可能是由于成熟阶段受损所致。两名患者的B细胞上IL-2受体水平升高，提示细胞内机制的发育受阻。一名患者可能存在免疫球蛋白同种型转换缺陷。
