Le Marchand L, Hankin J H, Kolonel L N, Beecher G R, Wilkens L R, Zhao L P
Cancer Research Center, University of Hawaii, Honolulu 96813.
Cancer Epidemiol Biomarkers Prev. 1993 May-Jun;2(3):183-7.
Using newly available food composition data for carotenoids, the authors reanalyzed a population-based case-control study of diet and lung cancer conducted in Hawaii in 1983-1985 (L. Le Marchand et al., J. Natl. Cancer Inst., 81: 1158-1164, 1989). The analysis included interviews with 230 men and 102 women with lung cancer and 597 men and 268 women as controls, frequency-matched to the patients by age and sex. A previously validated quantitative diet history assessed the usual intake of foods rich in carotenoids. After adjusting for smoking and other covariates, no association was found with lung cancer risk for dietary lycopene or beta-cryptoxanthin intake, whereas dose-dependent inverse associations of comparable magnitude were found for dietary beta-carotene, alpha-carotene, and lutein. When subjects were cross-classified by their joint intakes of the latter three carotenoids, those who had a high intake (> median) for all three had the lowest risk for lung cancer. In a similar two-way interaction analysis, the previously reported inverse association of lung cancer with vegetable consumption in these data was found to be stronger than that with intake of these three carotenoids. Consistent with our previous findings, this analysis provides further evidence for a protective effect of certain carotenoids against lung cancer and for the greater protection afforded by consuming a variety of vegetables compared to only foods rich in a particular carotenoid.
利用最新可得的类胡萝卜素食物成分数据，作者重新分析了1983 - 1985年在夏威夷开展的一项基于人群的饮食与肺癌病例对照研究（L. Le Marchand等人，《美国国家癌症研究所杂志》，81: 1158 - 1164, 1989）。该分析包括对230名男性和102名女性肺癌患者以及597名男性和268名女性对照者进行访谈，对照者按年龄和性别与患者进行频率匹配。一份先前经验证的定量饮食史评估了富含类胡萝卜素食物的通常摄入量。在对吸烟和其他协变量进行调整后，未发现膳食番茄红素或β - 隐黄质摄入量与肺癌风险存在关联，而对于膳食β - 胡萝卜素、α - 胡萝卜素和叶黄素，发现了具有相当程度的剂量依赖性负相关。当根据后三种类胡萝卜素的联合摄入量对受试者进行交叉分类时，三种类胡萝卜素摄入量均高（>中位数）的受试者患肺癌的风险最低。在一项类似的双向交互作用分析中，发现这些数据中先前报道的肺癌与蔬菜消费之间的负相关比与这三种类胡萝卜素摄入量之间的负相关更强。与我们之前的研究结果一致，该分析为某些类胡萝卜素对肺癌的保护作用以及与仅食用富含特定类胡萝卜素的食物相比，食用多种蔬菜能提供更大保护提供了进一步证据。
