Department of Occupational and Environmental Medicine, Ajou University School of Medicine, Suwon, Korea.
Cancer Sci. 2014 Jun;105(6):736-43. doi: 10.1111/cas.12405. Epub 2014 May 6.
Lung cancer is one of the most common cancers worldwide and is the leading cause of cancer-induced death in the USA. Although much attention has been focused on the anti-carcinogenic effect of consuming carotenoid-containing food or supplements, the results have been inconsistent. We investigated whether serum carotenoid levels were associated with the mortality risk of lung cancer in US adults using data from a nationally representative sample. The data were obtained from the Third Nutrition and Health Examination Survey (NHANES III) database and the NHANES III Linked Mortality File. A total of 10,382 participants aged over 20,years with available serum carotenoid levels and no other missing information on questionnaires and biomarkers at baseline (NHANES III) were included in the present study. Of the 10,382 participants, 161 subjects died due to lung cancer. We found that high serum levels of alpha-carotene and beta-cryptoxanthin at baseline were significantly associated with a lower risk of lung cancer death. When we stratified the risk by current smoking status, the risk of death of current smokers was significantly decreased to 46% (95% confidence interval, 31-94%) for alpha-carotene and 61% (95% confidence interval, 19-80%) for beta-cryptoxanthin. By contrast, no association was observed among never/former smokers at baseline. High serum levels of alpha-carotene and beta-cryptoxanthin are associated with a lower risk of lung cancer death in US adults.
肺癌是全球最常见的癌症之一，也是美国癌症相关死亡的主要原因。尽管人们已经关注了摄入含有类胡萝卜素的食物或补充剂的抗癌作用，但结果并不一致。我们使用来自具有全国代表性样本的第三次营养与健康检查调查（NHANES III）数据库和 NHANES III 关联死亡率文件的数据，研究了血清类胡萝卜素水平与美国成年人肺癌死亡率之间的关系。本研究共纳入了 10382 名年龄超过 20 岁、基线时具有可获得的血清类胡萝卜素水平且问卷和生物标志物无其他缺失信息的参与者。在这 10382 名参与者中，有 161 名因肺癌死亡。我们发现，基线时血清高水平的α-胡萝卜素和β-隐黄质与肺癌死亡风险降低显著相关。当我们按当前吸烟状况对风险进行分层时，发现当前吸烟者的死亡风险分别显著降低了 46%（95%置信区间，31-94%）和 61%（95%置信区间，19-80%），而对于从不吸烟者和前吸烟者，这种关联并不显著。高血清水平的α-胡萝卜素和β-隐黄质与美国成年人肺癌死亡风险降低相关。
