Simon L N, Glasky A J
Cancer Treat Rep. 1978 Nov;62(11):1963-9.
Isoprinosine appears to have a relatively low degree of both acute and chronic toxicity in both rodent and nonrodent species. Preclinical studies have demonstrated that isoprinosine can inhibit the growth of both DNA and RNA viruses as well as potentiate cell-mediated immune response both in vitro and in vivo. Clinical studies with rhinovirus, herpesvirus, and influenza virus infections in man demonstrated that isoprinosine treatment reduced clinical symptoms and enhanced certain cell-mediated immune responses compared to placebo-treated controls.
在啮齿动物和非啮齿动物物种中，异丙肌苷的急性和慢性毒性程度似乎都相对较低。临床前研究表明，异丙肌苷在体外和体内均可抑制DNA病毒和RNA病毒的生长，并增强细胞介导的免疫反应。对人类鼻病毒、疱疹病毒和流感病毒感染进行的临床研究表明，与接受安慰剂治疗的对照组相比，异丙肌苷治疗可减轻临床症状并增强某些细胞介导的免疫反应。
