Vecchi A, Sironi M, Spreafico F
Cancer Treat Rep. 1978 Nov;62(11):1975-9.
A preliminary characterization of the immunomodulatory activity of isoprinosine in mice was conducted in both normal and tumor-bearing mice. Under the experimental conditions employed, isoprinosine given ip and orally was found to possess some immunomodulatory capacity in various model systems. The compound appeared to preferentially influence T- but not B-cell responses; it did not apparently influence the functional capacity of macrophages, K cells, and NK cells.
在正常小鼠和荷瘤小鼠中对异丙肌苷的免疫调节活性进行了初步表征。在所采用的实验条件下，腹腔注射和口服给予的异丙肌苷在各种模型系统中均具有一定的免疫调节能力。该化合物似乎优先影响T细胞而非B细胞反应；它显然不影响巨噬细胞、K细胞和NK细胞的功能能力。
