Coenders C J, Kerbusch S M, Vossen J M
Department of Comparative & Physiological Psychology, University of Nijmegen, The Netherlands.
Brain Res Bull. 1993;32(1):7-10. doi: 10.1016/0361-9230(93)90311-x.
In order to investigate effects of haloperidol on response strategies, rats were confronted with an unsolvable discrimination problem after being injected with haloperidol (0.1 mg/kg, IP) or its solvent. The results showed that haloperidol-treated rats displayed systematic behaviour to a lesser degree than the control rats. Haloperidol did not affect reward-dependent response strategies. However, haloperidol did affect stimulus-dependent response strategies. Haloperidol-treated rats showed more response strategies based on visual or auditory cues, and less spatial response strategies than control rats. It is concluded that this differential effect of haloperidol is the consequence of the different nature of the stimuli (discretely present visual and auditory stimuli versus constantly present spatial stimuli).
为了研究氟哌啶醇对反应策略的影响，在给大鼠注射氟哌啶醇（0.1毫克/千克，腹腔注射）或其溶剂后，让它们面对一个无法解决的辨别问题。结果显示，与对照大鼠相比，接受氟哌啶醇治疗的大鼠表现出的系统性行为程度较低。氟哌啶醇不影响依赖奖励的反应策略。然而，氟哌啶醇确实影响依赖刺激的反应策略。与对照大鼠相比，接受氟哌啶醇治疗的大鼠表现出更多基于视觉或听觉线索的反应策略，而空间反应策略较少。得出的结论是，氟哌啶醇的这种差异效应是刺激性质不同（离散呈现的视觉和听觉刺激与持续存在的空间刺激）的结果。
