Haenlein M, Caul W F, Barrett R J
Pharmacol Biochem Behav. 1985 Dec;23(6):949-52. doi: 10.1016/0091-3057(85)90098-x.
Rats responding for food reinforcement were trained in a 2-lever drug discrimination task. Groups of rats were trained to discriminate one of four doses of amphetamine (0.0, 0.1, 0.3, or 0.5 mg/kg) from haloperidol (0.02 mg/kg). Both the rate of acquisition and level of discrimination at asymptote were a function of amphetamine training dose. Following acquisition of this discrimination, choice behavior was assessed in the absence of drug during two test sessions. Twenty-four hours following the second drug-free test session, chronic drug treatment commenced. Half of the animals received 10 mg/kg amphetamine for 10 consecutive days while the other half received 1 mg/kg haloperidol during the same period. Choice behavior was assessed during three 2.5-minute unreinforced drug-free test sessions 24, 48, and 72 hours following the chronic drug regimen. Following chronic haloperidol, animals responded as though a small dose of amphetamine had been administered, while following chronic amphetamine, they responded as though a small dose of haloperidol had been administered. Collectively, these results suggest that animals trained to discriminate amphetamine from haloperidol respond on the basis of a continuum of dopaminergic function. Further, this continuum can be used to elucidate the net effect of pharmacologically-induced alterations in dopaminergic function, as well as the effect of nonpharmacological manipulations that may result in dopaminergic changes.
对食物强化做出反应的大鼠在双杠杆药物辨别任务中接受训练。将大鼠分组训练，使其从氟哌啶醇（0.02mg/kg）中辨别四种剂量的苯丙胺（0.0、0.1、0.3或0.5mg/kg）之一。习得率和渐近线辨别水平均是苯丙胺训练剂量的函数。在习得这种辨别之后，在两个测试阶段中无药物情况下评估选择行为。在第二次无药物测试阶段后的24小时，开始进行慢性药物治疗。一半动物连续10天接受10mg/kg苯丙胺，而另一半在同一时期接受1mg/kg氟哌啶醇。在慢性药物治疗方案后的24、48和72小时，在三个2.5分钟无强化无药物测试阶段中评估选择行为。在接受慢性氟哌啶醇治疗后，动物的反应就好像给予了小剂量苯丙胺一样，而在接受慢性苯丙胺治疗后，它们的反应就好像给予了小剂量氟哌啶醇一样。总体而言，这些结果表明，经过训练从氟哌啶醇中辨别苯丙胺的动物是基于多巴胺能功能的连续体做出反应的。此外，这个连续体可用于阐明药理学诱导的多巴胺能功能改变的净效应，以及可能导致多巴胺能变化的非药理学操作的效应。
