Wirtshafter D, Asin K E
Pharmacol Biochem Behav. 1985 May;22(5):661-3. doi: 10.1016/0091-3057(85)90509-x.
Rats were trained to traverse a runway for food reward and speeds were measured in the start, run and goal segments of the alley. After eight days of acquisition training, subjects were tested for four days under conditions of either extinction or haloperidol pretreatment. Although both haloperidol and extinction produced a suppression of the running response, the pattern of this suppression in the three alley segments was quite different for the two conditions. Haloperidol tended to be more effective than extinction in slowing start speeds but less effective than extinction in reducing run and goal speeds. This differential effect of haloperidol and extinction on speeds in different alley segments provides further evidence that haloperidol-induced impairments in performance cannot result entirely from a blunting of primary reinforcement.
训练大鼠穿过跑道以获取食物奖励，并在跑道的起始、奔跑和终点段测量速度。经过八天的习得训练后，在消退或氟哌啶醇预处理条件下对受试者进行四天的测试。尽管氟哌啶醇和消退都产生了对奔跑反应的抑制，但在这两种条件下，三个跑道段中这种抑制的模式有很大不同。氟哌啶醇在减慢起始速度方面往往比消退更有效，但在降低奔跑和终点速度方面比消退效果更差。氟哌啶醇和消退对不同跑道段速度的这种差异效应进一步证明，氟哌啶醇引起的行为表现损伤不能完全归因于初级强化作用的减弱。
