Hermida R C, Fernández J R, Ayala D E, Mojón A, Rey A, Rodríguez-Cervilla J, Fernández-Lorenzo J R, Fraga J M
Bioengineering Laboratory, ETSI Telecommunicación, University of Vigo, Spain.
Chronobiol Int. 1993 Jun;10(3):214-23. doi: 10.3109/07420529309073890.
Genetic risk is a primary contributing factor to the predisposition of a newborn child to elevated blood pressure later in life. An index of this factor is needed to assess in the neonate the success or failure of preventive interventions instituted for the pregnant women. This index could be based on characteristics of blood pressure and heart rate variability measured during the first 2 days after birth. In the search for such an index, the systolic and diastolic blood pressures and heart rates of 127 newborn babies were automatically monitored at about 30-min intervals for 48 h with a Nippon Colin device, starting early after birth. Circadian parameters (obtained by the linear least-squares fit of a 24-h cosine curve to each individual series) and descriptive statistics for the three circulatory variables were used in a multiple regression analysis to compute a linear prediction function for the cardiovascular risk score. This score was obtained for each neonate on the basis of the presence or absence of overt cardiovascular disease, elevated blood pressure, or obesity across two generations, those of the newborn's parents and grandparents. Results from regression indicate that the best model includes the circadian amplitudes of systolic and diastolic blood pressure and the circadian ranges of systolic blood pressure and heart rate. The contributions from patroclinous versus matroclinous family history were then compared. Results show that linear prediction models include the same variables for both paternal and maternal cardiovascular risk score. These results provide a neonatal index of cardiovascular risk, to be used later for the evaluation of the effects on the newborn of intervention for the pregnant women.
遗传风险是新生儿日后患高血压易感性的一个主要促成因素。需要一个该因素的指标来评估针对孕妇采取的预防性干预措施在新生儿身上的成败。这个指标可以基于出生后头两天测量的血压和心率变异性特征。在寻找这样一个指标的过程中，使用日本 Colin 设备从出生后早期开始，每隔约 30 分钟自动监测 127 名新生儿的收缩压、舒张压和心率，持续 48 小时。昼夜节律参数（通过对每个个体序列进行 24 小时余弦曲线的线性最小二乘法拟合获得）以及这三个循环变量的描述性统计数据被用于多元回归分析，以计算心血管风险评分的线性预测函数。根据两代人（新生儿的父母和祖父母）中是否存在明显的心血管疾病、高血压或肥胖，为每个新生儿获得该评分。回归结果表明，最佳模型包括收缩压和舒张压的昼夜节律幅度以及收缩压和心率的昼夜节律范围。然后比较了父系家族史与母系家族史的贡献。结果表明，父系和母系心血管风险评分的线性预测模型包含相同的变量。这些结果提供了一个新生儿心血管风险指标，随后可用于评估针对孕妇的干预措施对新生儿的影响。
