松果体对雄性Wistar大鼠格林上皮瘤生长过程的影响。

Effects of the pineal gland on the growth processes of Guerin epithelioma in male Wistar rats.

作者信息

Lewiński A, Sewerynek E, Wajs E, Lopaczyński W, Sporny S

机构信息

Laboratory of Thyrology, University School of Medicine, Poland.

出版信息

Cytobios. 1993;73(293):89-94.

PMID:8319500

Abstract

The effects of pinealectomy (PX) and melatonin (Mel) administration on the growth processes of Guerin epithelioma, a malignant tumour derived from spontaneous cancer in Wistar rat uterus, was investigated in five groups of male rats. The mean life span of the rats bearing Guerin tumours (GT) and subjected to PX was shorter than in animals with an intact pineal gland. Mel did not affect the lifespan in rats with intact pineals or in those subjected to PX. Mel decreased the mitotic activity of GT cells in rats with and without the pineal gland. Pathomorphological examination revealed high malignancy of the primary tumour but no metastases. The results confirmed the important role of the pineal gland in 'oncostasis'.

摘要

在五组雄性大鼠中，研究了松果体切除（PX）和褪黑素（Mel）给药对源于Wistar大鼠子宫自发性癌的恶性肿瘤——格林上皮瘤生长过程的影响。携带格林肿瘤（GT）并接受PX的大鼠的平均寿命比松果体完整的动物短。Mel对松果体完整的大鼠或接受PX的大鼠的寿命没有影响。Mel降低了有或没有松果体的大鼠中GT细胞的有丝分裂活性。病理形态学检查显示原发性肿瘤具有高恶性，但无转移。结果证实了松果体在“肿瘤抑制”中的重要作用。