Yoto Y, Kudoh T, Suzuki N, Katoh S, Matsunaga Y, Chiba S
Department of Pediatrics, School of Medicine, Sapporo Medical University, Japan.
Eur J Haematol. 1993 May;50(5):255-7. doi: 10.1111/j.1600-0609.1993.tb00158.x.
Human parvovirus B19 (B19) has a remarkable tissue-tropism for erythroid elements--from erythroid precursors (BFU-E, CFU-E) to erythroblasts. B19 is thought to be incapable of propagating in cells other than erythroid progenitors. Leukocytopenia and thrombocytopenia sometimes occur in addition to erythrocytopenia in patients with B19 infection. We retrospectively investigated the possible cause of thrombocytopenia by B19 infection in 23 patients with thrombocytopenia admitted to our hospital in the past 5 years. Two patients were found to be infected by B19. Mild thrombocytopenia in both cases was thought to be an early event in B19 infection.
人细小病毒B19（B19）对红系细胞具有显著的组织嗜性，从红系前体细胞（爆式红系集落形成单位、红系集落形成单位）到幼红细胞。B19被认为无法在除红系祖细胞以外的细胞中增殖。B19感染患者除红细胞减少外，有时还会出现白细胞减少和血小板减少。我们回顾性调查了过去5年我院收治的23例血小板减少患者中B19感染导致血小板减少的可能原因。发现2例患者感染了B19。两例患者的轻度血小板减少被认为是B19感染的早期事件。
