1型核糖体失活蛋白皂草素5对蚕豆核糖体的分子作用。
Molecular action of the type 1 ribosome-inactivating protein saporin 5 on Vicia sativa ribosomes.
作者信息
Iglesias R, Arias F J, Rojo M A, Escarmis C, Ferreras J M, Girbés T
机构信息
Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Valladolid, Spain.
出版信息
FEBS Lett. 1993 Jul 5;325(3):291-4. doi: 10.1016/0014-5793(93)81091-d.
The type 1 ribosome-inactivating protein (RIP) saporin 5 isolated from seeds of Saponaria officinalis L. strongly inhibited translation carried out by Vicia sativa L. purified ribosomes. The toxin multidepurinated V. sativa rRNA, which upon treatment with acid aniline releases several RNA fragments including an RNA fragment of approximately 370 nucleotides the 5'-end sequence of which was 5'-GAGGAACG-3'.
从肥皂草种子中分离出的1型核糖体失活蛋白（RIP）皂草素5强烈抑制了蚕豆纯化核糖体进行的翻译。该毒素使蚕豆核糖体RNA多次脱嘌呤，在用酸性苯胺处理后会释放出几个RNA片段，包括一个约370个核苷酸的RNA片段，其5'端序列为5'-GAGGAACG-3'。
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