大鼠化学诱导肝细胞癌对二磷酸吡哆醛锰的摄取。对比剂增强磁共振成像、肿瘤分化与血管生成之间的相关性。
The uptake of manganese dipyridoxal-diphosphate by chemically induced hepatocellular carcinoma in rats. A correlation between contrast-media-enhanced magnetic resonance imaging, tumor differentiation, and vascularization.
作者信息
Ni Y, Marchal G, Zhang X, Van Hecke P, Michiels J, Yu J, Rummeny E, Lodemann K P, Baert A L
机构信息
Department of Radiology, University Hospitals K.U., Leuven, Belgium.
出版信息
Invest Radiol. 1993 Jun;28(6):520-8. doi: 10.1097/00004424-199306000-00011.
OBJECTIVES AND RATIONALE
Negative enhancement of implanted liver tumors has been achieved in preclinical studies on manganese dipyridoxal-diphosphate (Mn-DPDP), a new hepatobiliary specific contrast agent for magnetic resonance imaging (MRI). The authors investigated the effects of Mn-DPDP on primary liver cancer and its possible mechanisms.
METHODS
Magnetic resonance imaging was performed in 15 rats with chemically induced hepatocellular carcinoma (HCC) before and after Mn-DPDP injection. Both tumor-liver contrast-to-noise ratio and absolute tumor enhancement were evaluated and compared with the MRI results of a nonspecific contrast agent, gadolinium-DOTA, and correlated with corresponding microangiographic and histologic findings.
RESULTS
Mn-DPDP injection led to a persistent positive enhancement in differentiated solid HCCs (22/23) with maximal conspicuity at 24 hours. Undifferentiated HCCs were all delineated by a prompt negative enhancement (20/20) with maximal conspicuity within 30 minutes.
目的与理论依据
在一项针对二磷酸吡哆醛锰（Mn-DPDP）的临床前研究中，已实现植入性肝肿瘤的负性强化。Mn-DPDP是一种用于磁共振成像（MRI）的新型肝胆特异性造影剂。作者研究了Mn-DPDP对原发性肝癌的影响及其可能机制。
方法
对15只化学诱导的肝细胞癌（HCC）大鼠在注射Mn-DPDP前后进行磁共振成像。评估肿瘤-肝脏对比噪声比和绝对肿瘤强化，并与非特异性造影剂钆-多胺酸（gadolinium-DOTA）的MRI结果进行比较，并与相应的微血管造影和组织学结果相关联。
结果
注射Mn-DPDP后，分化型实性HCC（22/23）出现持续的正性强化，在24小时时显示度最高。未分化型HCC均表现为快速负性强化（20/20），在30分钟内显示度最高。
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