Sato Y, Abe M, Takaki R
First Department of Medicine, Medical College of Oita, Japan.
Biochem Biophys Res Commun. 1990 Oct 30;172(2):595-600. doi: 10.1016/0006-291x(90)90715-y.
Platelet factor 4 (PF-4) blocked the binding of basic fibroblast growth factor (bFGF) to the plasma membrane receptor. Five micrograms/ml of PF-4 completely blocked the specific binding of bFGF to the receptor of NIH 3T3 cells. Endogenously produced bFGF regulates the spontaneous migration of bovine aortic endothelial (BAE) cells as an autocrine factor (Sato and Rifkin, 1988). PF-4 inhibited the spontaneous migration of BAE cells in a reversible and dose dependent manner. The inhibition reached maximum at 5 micrograms/ml of PF-4, where the binding of bFGF to the receptor was completely blocked.
血小板因子4（PF-4）可阻断碱性成纤维细胞生长因子（bFGF）与质膜受体的结合。每毫升5微克的PF-4可完全阻断bFGF与NIH 3T3细胞受体的特异性结合。内源性产生的bFGF作为一种自分泌因子调节牛主动脉内皮（BAE）细胞的自发迁移（佐藤和里夫金，1988年）。PF-4以可逆且剂量依赖的方式抑制BAE细胞的自发迁移。在每毫升5微克的PF-4时抑制作用达到最大，此时bFGF与受体的结合被完全阻断。
