Ciombor D M, Aaron R K
Department of Orthopaedics, Brown University, Providence, Rhode Island 00928.
J Cell Biochem. 1993 May;52(1):37-41. doi: 10.1002/jcb.240520106.
Endochondral ossification is a basic physiological process in limb development and is central to bone repair and linear growth. Factors which regulate endochondral ossification include several biophysical and biochemical agents and are of interest from clinical and biological perspectives. One of these agents, electric stimulation, has been shown to result in enhanced synthesis of extracellular matrix, calcification, and bone formation in a number of experimental systems and is the subject of this review. The effects of electric stimulation have been studied in embryonic limb rudiments, growth plates, and experimental endochondral ossification induced with decalcified bone matrix and, in all these models, endochondral ossification has been enhanced. It is not known definitively whether electric fields stimulate cell differentiation or modulate an increased number of molecules synthesized by committed cell population and this is a fertile area of current study.
软骨内成骨是肢体发育中的一个基本生理过程，对于骨修复和线性生长至关重要。调节软骨内成骨的因素包括多种生物物理和生化因子，从临床和生物学角度来看都备受关注。其中一种因子，即电刺激，已在多个实验系统中显示可导致细胞外基质合成增加、钙化和骨形成增强，本文将对此进行综述。电刺激的作用已在胚胎肢体原基、生长板以及用脱钙骨基质诱导的实验性软骨内成骨中进行了研究，在所有这些模型中，软骨内成骨均得到增强。目前尚不确定电场是刺激细胞分化还是调节已分化细胞群体合成的分子数量增加，这是当前研究的一个热点领域。
