Bosman G J, Visser F E, De Man A J, Bartholomeus I G, De Grip W J
Department of Biochemistry, University of Nijmegen, The Netherlands.
Neurobiol Aging. 1993 May-Jun;14(3):223-8. doi: 10.1016/0197-4580(93)90004-u.
An increase in erythrocyte-bound IgG, enhanced breakdown of band 3, and changes in erythrocyte anion transport characteristics are observed in individuals with Down's Syndrome. We interpret these data as indicative for a disturbance of normal erythrocyte aging. A comparison of three groups of individuals with Down's Syndrome in various stages of dementia of the Alzheimer type did not reveal a correlation between the erythrocyte membrane changes and age or stage of dementia. Considering previously obtained data on patients with senile dementia of the Alzheimer type (7), these results may signify that parameters of disturbed erythrocyte aging represent presymptomatic markers of Alzheimer-type dementia.
在唐氏综合征患者中观察到红细胞结合IgG增加、带3蛋白的分解增强以及红细胞阴离子转运特性的改变。我们将这些数据解释为正常红细胞衰老受到干扰的指标。对三组处于阿尔茨海默型痴呆不同阶段的唐氏综合征患者进行比较，未发现红细胞膜变化与痴呆的年龄或阶段之间存在相关性。考虑到先前获得的关于阿尔茨海默型老年痴呆症患者的数据（7），这些结果可能表明红细胞衰老紊乱的参数代表了阿尔茨海默型痴呆的症状前标志物。
