Bosman G J, Janzing J G, Bartholomeus I G, De Man A J, Zitman F G, De Grip W J
Department of Biochemistry, University of Nijmegen, The Netherlands.
Neurobiol Aging. 1997 May-Jun;18(3):291-5. doi: 10.1016/s0197-4580(97)80310-7.
An increase in erythrocyte-bound IgG and enhanced breakdown of the erythrocyte anion exchanger band 3, characteristics of normal erythrocyte aging are observed in old, healthy individuals when compared with young donors. These findings indicate that the rate of cellular aging increases with organismal aging. Results from previous studies on the same parameters have suggested that the erythrocyte aging process is disturbed in patients in advanced stages of Alzheimer type dementia, and in individuals with Down's syndrome who show no signs of dementia. In this study we find no changes in erythrocyte aging parameters in old individuals in beginning stages of dementia of various etiologies. We conclude that, in general, characteristics of disturbed erythrocyte aging cannot serve as presymptomatic markers of Alzheimer-type dementia.
与年轻捐赠者相比，在健康的老年人中观察到红细胞结合IgG增加以及红细胞阴离子交换蛋白带3的分解增强，这是正常红细胞衰老的特征。这些发现表明细胞衰老速率随机体衰老而增加。先前对相同参数的研究结果表明，在阿尔茨海默型痴呆晚期患者以及无痴呆症状的唐氏综合征患者中，红细胞衰老过程受到干扰。在本研究中，我们发现不同病因早期痴呆的老年个体的红细胞衰老参数没有变化。我们得出结论，一般来说，红细胞衰老紊乱的特征不能作为阿尔茨海默型痴呆的症状前标志物。
