Research to understand and control Salmonella enteritidis in chickens and eggs.

When it became evident that the association of human Salmonella enteritidis (SE) outbreaks with the consumption of contaminated Grade A eggs posed a threat to public health and to the economic viability of the egg industry, research programs were rapidly initiated to investigate the many unanswered questions about SE in eggs and chickens. Research efforts have focused on the dynamics of deposition, survival, and growth of SE in eggs, the pathogenesis of SE in chickens, strategies for detecting SE-infected flocks, opportunities for intervening to prevent infection, the sources of SE in laying flocks, options for effectively cleaning poultry houses, and the epidemiology of SE infections of humans and chickens. This research has provided a substantially better understanding of the SE problem in poultry, but many further questions about the basis for and the prevention of eggborne transmission of SE remain to be answered.