三酰甘油对体外红细胞变形性的影响。
Effect of triacylglycerols on erythrocyte deformability in vitro.
作者信息
Hong C Y, Lai L J, Shiao M S, Chiang B N
机构信息
Department of Medicine, Veterans General Hospital, Taipei, Taiwan, ROC.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 1993 May;48(5):351-3. doi: 10.1016/0952-3278(93)90114-c.
With Reid's filtration technique as a bioassay for evaluating red blood cell (RBC) deformability, we found that tripalmitolein, triolein and trilinolein improved the deformability of calcium-loaded RBC while glycerol, linoleic acid, dilinoleoyl phosphatidyl choline, trilpalmitin, tristearin, trilinolenin and triarachidonin did not. Maximal effect of tripalmitolein, triolein and trilinolein was achieved at 10(-9), 10(-10) and 10(-8) M respectively. We propose that only those triacylglycerols which contain fatty acids with one or two double bonds could modify RBC membrane fluidity and improve RBC deformability.
采用里德过滤技术作为评估红细胞（RBC）变形性的生物测定方法，我们发现三棕榈油酸甘油酯、三油酸甘油酯和三亚油酸甘油酯可改善钙负载红细胞的变形性，而甘油、亚油酸、二亚油酰磷脂酰胆碱、三棕榈酸甘油酯、三硬脂酸甘油酯、三亚麻酸甘油酯和三花生四烯酸甘油酯则不能。三棕榈油酸甘油酯、三油酸甘油酯和三亚油酸甘油酯的最大效应分别在10^(-9)、10^(-10)和10^(-8) M时达到。我们提出，只有那些含有一个或两个双键脂肪酸的三酰甘油能够改变红细胞膜流动性并改善红细胞变形性。
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