Leitman I M, Fisher M L, McKinley M J, Rothman R, Ward R J, Reiner D S, Tortolani A J
Department of Surgery, North Shore University Hospital-Cornell University Medical College, Manhasset, New York 11030.
Surg Gynecol Obstet. 1993 Jun;176(6):527-33.
Laparoscopic cholecystectomy (LC) has rapidly become the procedure of choice for symptomatic cholelithiasis. The perioperative diagnosis and modern treatment of suspected stones of the common bile duct (CBD) remains controversial. A database of 573 patients undergoing LC was compiled during an 11 month period. Sixty-seven patients (47 females, 20 males) (13 percent) were suspected of having CBD stones based upon clinical, laboratory and roentgenographic evidence. Fifty-two patients underwent endoscopic retrograde cholangiopancreatography (ER-CP) (45 preoperative and seven postoperative). Seventeen patients were studied with intraoperative cholangiogram (IOC). The indications for cholangiography (either ERCP or IOC) included pancreatitis (group 1), clinical history suggestive of CBD stones, but normal preoperative liver function tests (LFT) (group 2), cholangitis (group 3), grossly abnormal LFT (group 4) and dilated CBD (greater than 7 millimeters on sonogram) (group 5). The incidence of CBD stones was three of 14 (21 percent) in group 1, six of 20 (30 percent) in group 2, two of three (67 percent) in group 3, 16 of 26 (62 percent) in group 4 and two of four (50 percent) in group 5. Overall, 29 patients (23 females and six males) had stones retrieved from the CBD. Of the 52 ERCP, 20 endoscopic sphincterotomies were performed for documented CBD stones. Of the group that had pre-LC ERCP, three (6 percent) ultimately required an open procedure. There were three instances of post-ERCP pancreatitis (6 percent) and ERCP was not able to opacify or clear the CBD in four instances. Seven patients had postoperative ERCP with successful retrieval of retained CBD stones (100 percent). Of the 17 IOC, eight were positive--two patients underwent laparoscopic clearance of the CBD and six required conversion to an open procedure. There were no deaths or extensive complications. Total and direct bilirubin, alkaline phosphatase and serum glutamic pyruvic transaminase were independently related to the presence of a CBD stone, while demographic data, past medical history, preoperative symptoms, leukocyte count, vital signs, amylase, serum glutamic-oxalacetic transaminase nuclear scintigraphic visualization of the duodenum or size of CBD on sonography, were not. No patient with biliary pancreatitis had CBD stones without abnormalities in the LFT or the preoperative sonogram. ERCP is a useful technique to clear the CBD pre-LC. However, ERCP in patients with biliary pancreatitis, but otherwise normal preoperative tests, has a low yield. In this group of patients, IOC is an appropriate alternative to pre-LC ERCP.
腹腔镜胆囊切除术(LC)已迅速成为有症状胆结石的首选治疗方法。胆总管(CBD)可疑结石的围手术期诊断和现代治疗仍存在争议。在11个月期间收集了一个包含573例行LC患者的数据库。67例患者(47例女性,20例男性)(13%)基于临床、实验室和影像学证据怀疑有CBD结石。52例患者接受了内镜逆行胰胆管造影(ERCP)(45例术前,7例术后)。17例患者进行了术中胆管造影(IOC)。胆管造影(ERCP或IOC)的指征包括胰腺炎(第1组)、临床病史提示CBD结石但术前肝功能检查(LFT)正常(第2组)、胆管炎(第3组)、LFT严重异常(第4组)和CBD扩张(超声检查大于7毫米)(第5组)。CBD结石的发生率在第1组中为14例中的3例(21%),第2组中为20例中的6例(30%),第3组中为3例中的2例(67%),第4组中为26例中的16例(62%),第5组中为4例中的2例(50%)。总体而言,29例患者(23例女性和6例男性)从CBD中取出了结石。在52例ERCP中,对已证实的CBD结石进行了20例内镜括约肌切开术。在术前进行ERCP的患者组中,3例(6%)最终需要进行开放手术。有3例ERCP术后胰腺炎(6%),4例ERCP未能使CBD显影或清除CBD。7例患者术后进行ERCP并成功取出残留的CBD结石(100%)。在17例IOC中,8例为阳性——2例患者接受了腹腔镜下CBD清除术,6例需要转为开放手术。没有死亡或严重并发症。总胆红素和直接胆红素、碱性磷酸酶和血清谷丙转氨酶与CBD结石的存在独立相关,而人口统计学数据、既往病史、术前症状、白细胞计数、生命体征、淀粉酶、血清谷草转氨酶、十二指肠核素显像或超声检查中CBD的大小则无关。没有一例胆源性胰腺炎患者的CBD结石在LFT或术前超声检查中无异常。ERCP是在LC术前清除CBD的有用技术。然而,对于胆源性胰腺炎但术前其他检查正常的患者,ERCP的阳性率较低。在这组患者中,IOC是LC术前ERCP的合适替代方法。