[痘苗病毒“MVA”免疫对兔感染牛痘病毒“OPV 85”的有效性]
[The effectiveness of immunization with vaccinia virus type "MVA" against an infection with cowpox virus type "OPV 85" in rabbits].
作者信息
Munz E, Linckh S, Renner-Müller I C, Reimann M
机构信息
Institut für Vergleichende Tropenmedizin und Parasitologie, Tierärztliche Fakultät, Universität München, Deutschland.
出版信息
Zentralbl Veterinarmed B. 1993 Mar;40(2):131-40.
The immunological efficacy of vacciniavirus "MVA" was tested against a dermal and intradermal infection with cowpoxvirus "OPV 85" in rabbits: A single vaccination with "MVA" provided only insufficient immunity, a revaccination induced good immunity. Intramuscular immunizations protected better than subcutaneous applications. Immunized rabbits showed "revaccination reactions" after infection with "OPV 85" indicating a cellular immunity. After immunization with "MVA" and after infection with cowpoxvirus "OPV 85" all rabbits developed N- and ELISA-antibodies. HAI-antibodies were not found after immunization, but indicated a multiplication of cowpoxvirus after challenge. Vacciniavirus "MVA" is suggested for immunization of man and animal against possible infections with cowpoxvirus and cowpoxlike viruses.
在兔身上测试了痘苗病毒“MVA”针对牛痘病毒“OPV 85”的皮肤和皮内感染的免疫效果：单次接种“MVA”仅提供了不足的免疫力，再次接种诱导了良好的免疫力。肌肉内免疫比皮下接种提供了更好的保护。免疫的兔子在感染“OPV 85”后出现“再次接种反应”，表明存在细胞免疫。在用“MVA”免疫后以及在感染牛痘病毒“OPV 85”后，所有兔子都产生了N抗体和ELISA抗体。免疫后未发现血凝抑制（HAI）抗体，但在攻击后表明牛痘病毒发生了增殖。建议使用痘苗病毒“MVA”对人和动物进行免疫，以预防可能感染牛痘病毒和牛痘样病毒。
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