Murakawa Y, Ajiki K, Usui M, Yamashita T, Oikawa N, Inoue H
Second Department of Internal Medicine, Tokyo University Hospital, Japan.
Am Heart J. 1993 Jul;126(1):108-14. doi: 10.1016/s0002-8703(07)80016-0.
Autonomic heart rate control was assessed by power spectral analysis of heart rate variability in 24-hour ambulatory electrocardiographic recordings from 23 healthy subjects, 14 patients with coronary artery disease without cardiac dysfunction, and 14 patients with diabetes mellitus. The log value of the ratio of the low-frequency component (LF = 0.04 to 0.15 Hz) to the high-frequency component (HF = 0.15 to 0.5 Hz) and logHF were employed as indexes of sympathetic and parasympathetic activity, respectively. Diurnal and nocturnal logLF, logHF, and log(LF/HF) values were calculated for heart rates of 60, 70, and 80 beats/min. Intergroup differences among these three variables were not significant at any heart rate. Although a heart rate-related decrease in logHF was generally observed, the relationship between log(LF/HF) and heart rate was not consistent. The correlation between diurnal and nocturnal logHF values was significant at all three heart rates (r = 0.63, 0.87, and 0.59), whereas the diurnal log(LF/HF) was correlated with the nocturnal value only at 70 beats/min (r = 0.77). These results suggest that the heart rate during normal daily activities is a reliable indicator of parasympathetic tone, if not sympathetic tone, in healthy subjects and patients with coronary artery disease or diabetes mellitus.
通过对23名健康受试者、14名无心脏功能障碍的冠心病患者和14名糖尿病患者的24小时动态心电图记录进行心率变异性的功率谱分析，评估自主心率控制情况。低频成分（LF = 0.04至0.15赫兹）与高频成分（HF = 0.15至0.5赫兹）之比的对数值以及logHF分别用作交感神经和副交感神经活动的指标。计算了心率为60、70和80次/分钟时的日间和夜间logLF、logHF以及log（LF/HF）值。在任何心率下，这三个变量的组间差异均无统计学意义。虽然一般观察到logHF随心率下降，但log（LF/HF）与心率之间的关系并不一致。在所有三个心率下，日间和夜间logHF值之间的相关性均具有统计学意义（r = 0.63、0.87和0.59），而日间log（LF/HF）仅在70次/分钟时与夜间值相关（r = 0.77）。这些结果表明，在健康受试者以及冠心病或糖尿病患者中，正常日常活动期间的心率即使不是交感神经张力的可靠指标，也是副交感神经张力的可靠指标。
