Fontana M, Massironi E, Rossi A, Vaglia P, Gancia G P, Tagliabue P, Principi N
Fourth Department of Paediatrics, University of Milan Medical School, Italy.
Arch Dis Child. 1993 May;68(5 Spec No):602-3. doi: 10.1136/adc.68.5_spec_no.602.
Few data are available for ranitidine pharmacokinetics in the first few days of life. Twenty seven newborn infants were treated with intravenous ranitidine because they were vomiting blood, although they had a negative Apt's test. Each infant provided two blood samples at randomly selected times 30-360 minutes after a 2.4 mg/kg intravenous bolus of ranitidine. A single exponential equation for the concentration-time graph was fitted to the mean serum concentrations at different times. From this model the following mean (SD) measurements wer derived: elimination half life, 207.1 (19.1) minutes; total volume of distribution, 1.52 (0.91) l/kg; and total plasma clearance, 5.02 (0.46) ml/kg/min. Assuming that these measurements do not change with different administered doses, regimens can be derived to assist in planning ranitidine treatment in newborn infants.
关于雷尼替丁在出生后最初几天的药代动力学数据很少。27名新生儿因吐血接受静脉注射雷尼替丁治疗，尽管他们的阿普特试验呈阴性。在静脉注射2.4mg/kg雷尼替丁大剂量后30 - 360分钟的随机选定时间，每个婴儿提供两份血样。将浓度 - 时间图的单指数方程拟合到不同时间的平均血清浓度。从该模型得出以下平均（标准差）测量值：消除半衰期为207.1（19.1）分钟；分布总体积为1.52（0.91）升/千克；总血浆清除率为5.02（0.46）毫升/千克/分钟。假设这些测量值不会因给药剂量不同而改变，则可以推导出给药方案，以协助规划新生儿的雷尼替丁治疗。
