雷尼替丁对五肽胃泌素刺激的夜间胃酸分泌的抑制作用。一种新型H2受体拮抗剂。
Inhibition of pentagastrin-stimulated and nocturnal gastric secretion by ranitidine. A new H2-receptor antagonist.
作者信息
Peden N R, Saunders J H, Wormsley K G
出版信息
Lancet. 1979 Mar 31;1(8118):690-2. doi: 10.1016/s0140-6736(79)91146-2.
PMID:85934
Abstract
Ranitidine hydrochloride (an H2-receptor-blocking drug which does not contain the imidazole nucleus of histamine) powerfully inhibited nocturnal and pentagastrin-stimulated gastric secretion in fifteen patients with duodenal ulceration. The drug is satisfactorily absorbed and therefore warrants clinical trial.
摘要
盐酸雷尼替丁（一种不含组胺咪唑核的H2受体阻断药）能有效抑制15例十二指肠溃疡患者的夜间及五肽胃泌素刺激的胃酸分泌。该药吸收良好，因此值得进行临床试验。
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