肌动蛋白聚合在细胞运动中的作用：分子与模型
Role of actin polymerization in cell locomotion: molecules and models.
作者信息
Bearer E L
机构信息
Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island.
出版信息
Am J Respir Cell Mol Biol. 1993 Jun;8(6):582-91. doi: 10.1165/ajrcmb/8.6.582.
Abstract
Actin filaments forming at the anterior margin of a migrating cell are essential for the formation of filopodia, lamellipodia, and pseudopodia, the "feet" that the cell extends before it. These structures in turn are required for cell locomotion. Yet the molecular nature of the "nucleator" that seeds the polymerization of actin at the leading edge is unknown. Recent advances, including video microscopy of actin dynamics, discovery of proteins unique to the leading edge such as ponticulin, the Mab 2E4 antigen, and ABP 120, and novel experimental models of actin polymerization such as the actin-based movements of intracellular parasites, promise to shed light on this problem in the near future.
摘要
在迁移细胞前缘形成的肌动蛋白丝对于丝状伪足、片状伪足和伪足的形成至关重要，这些“足部”是细胞在前行之前伸展出来的结构。而这些结构反过来又是细胞运动所必需的。然而，在前缘引发肌动蛋白聚合的“成核剂”的分子本质尚不清楚。最近的进展，包括对肌动蛋白动力学的视频显微镜观察、对前缘特有的蛋白质如膜桥蛋白、单克隆抗体2E4抗原和ABP 120的发现，以及肌动蛋白聚合的新型实验模型如细胞内寄生虫基于肌动蛋白的运动，有望在不久的将来阐明这个问题。
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