Sires B S, Geggel H S, Heffernan J T, Crane R D, Holds J B
Department of Ophthalmology, Virginia Mason Clinic and Research Center, Seattle Washington.
Ophthalmic Plast Reconstr Surg. 1993 Jun;9(2):112-9. doi: 10.1097/00002341-199306000-00006.
Implanted allogeneic demineralized bone particles (DBP) may be transformed into endochondral bone by inductive or conductive new bone formation. Using a rabbit model, enucleation or evisceration was performed, and DBP was implanted into the socket. Histology confirmed endochondral bone formation in both groups. A morphologic difference existed between enucleation and evisceration: compact bone was produced following evisceration, and cancellous bony spheres were formed following enucleation. Serial quantitative computed tomography (qCT) was performed to monitor mineral density and proved to be an ideal technique to monitor bone mineralization noninvasively in the postoperative orbit. Bone mineral density (BMD, mg/ml) increased approximately 300% in DBP implanted orbits when compared to controls at 6 weeks. The ideal mass/volume ratio of DBP to socket volume was 400 mg/ml. The rapidly formed bone is well vascularized and creates a stable integrated orbital implant, following enucleation and evisceration surgery. DBP implantation into the central orbit results in inductive bone formation with interesting potential in socket and orbit reconstruction.
植入的同种异体脱矿骨颗粒（DBP）可通过诱导性或传导性新骨形成转化为软骨内骨。利用兔模型，进行眼球摘除或脏器摘除，然后将DBP植入眼窝。组织学证实两组均有软骨内骨形成。眼球摘除和脏器摘除之间存在形态学差异：脏器摘除后产生致密骨，眼球摘除后形成松质骨球。进行了系列定量计算机断层扫描（qCT）以监测矿物质密度，结果证明这是一种在术后眼眶中无创监测骨矿化的理想技术。与对照组相比，植入DBP的眼眶在6周时骨矿物质密度（BMD，mg/ml）增加了约300%。DBP与眼窝体积的理想质量/体积比为400 mg/ml。在眼球摘除和脏器摘除手术后，快速形成的骨具有良好的血管化，并形成稳定的整合眼眶植入物。将DBP植入眼眶中央会导致诱导性骨形成，在眼窝和眼眶重建方面具有有趣的潜力。
