Maiz H B, Safar M, Weiss Y, Ayed H B, Milliez P
Clin Nephrol. 1977 Jan;7(1):26-30.
Effective surgical treatment was carried out in 67 patients who were selected from a population of 336 subjects with renovascular hypertension. Split renal function studies and estimation of plasma renin activity in both renal veins were made to demonstrate the functional significance of the stenosis. The degree of disturbance of these tests did not correlate with the preoperative blood pressure level. The percentage decrease in postoperative blood pressure was directly related to the preoperative blood pressure (P less than 0.01). In 23 postoperative patients followed yearly for 5 years, the blood pressure increased progressively and was positively correlated with the duration of follow up (P less than 0.02). Patients with renovascular hypertension had a lower frequency of blood group 0 and a higher frequency of blood group A than did normotensive controls. The results of the study suggest that, in renovascular hypertension, the antihypertensive effect of surgical treatment is not exclusively related to the physiological consequence of the stenosis and that nonspecific factors, possibly of genetic origin, may determine the blood pressure response after surgical treatment.
对从336例肾血管性高血压患者中挑选出的67例患者实施了有效的外科治疗。进行了分肾功能研究及双侧肾静脉血浆肾素活性测定，以证实狭窄的功能意义。这些检查的紊乱程度与术前血压水平无关。术后血压下降的百分比与术前血压直接相关（P<0.01）。在23例术后患者中，每年随访5年，血压逐渐升高，且与随访时间呈正相关（P<0.02）。与血压正常的对照组相比，肾血管性高血压患者中0型血的频率较低，A型血的频率较高。研究结果表明，在肾血管性高血压中，外科治疗的降压效果并非仅与狭窄的生理后果相关，非特异性因素（可能源于遗传）可能决定外科治疗后的血压反应。
