肾炎糖苷及相关化合物的合成

Syntheses of nephritogenoside and related compounds.

作者信息

Takeda T, Kojima K, Ogihara Y

机构信息

Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.

出版信息

Carbohydr Res. 1993 Apr 23;243(1):79-89. doi: 10.1016/0008-6215(93)84082-h.

DOI:10.1016/0008-6215(93)84082-h

PMID:8324766

Abstract

Nephritogenoside has been prepared by coupling of the acyl azide derivative of a N-triglycosyl dipeptide, derived from the corresponding hydrazide derivative of O-(2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl)-(1-->6)-O-(2,3,4-tri-O -acetyl - beta-D-glucopyranosyl)-(1-->6)-2,3-di-O-benzyl-1-N-[N-(tert-butoxycarbon yl)- L-aspart-1-oyl-(L-proline methyl ester)-4-oyl]-alpha-D-glucopyranosylamine, with a nonadecapeptide, followed by deprotection of the desired protected nephritogenoside. The N-triglycosyl pentapeptide also has been prepared as a model compound.

摘要

肾炎糖苷是通过将一种 N-三糖基二肽的酰基叠氮衍生物与一种十九肽偶联制备而成，该 N-三糖基二肽衍生自 O-(2,3,4,6-四-O-乙酰基-α-D-吡喃葡萄糖基)-(1→6)-O-(2,3,4-三-O-乙酰基-β-D-吡喃葡萄糖基)-(1→6)-2,3-二-O-苄基-1-N-[N-(叔丁氧羰基)-L-天冬氨酸-1-酰基-(L-脯氨酸甲酯)-4-酰基]-α-D-吡喃葡萄糖胺的相应酰肼衍生物，随后对所需的保护型肾炎糖苷进行脱保护。N-三糖基五肽也已作为模型化合物制备出来。