一种N-三糖基二肽的α和β异头物的合成。
Synthesis of the alpha and beta anomer of an N-triglycosyl dipeptide.
作者信息
Takeda T, Utsuno A, Okamoto N, Ogihara Y, Shibata S
机构信息
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
出版信息
Carbohydr Res. 1990 Oct 15;207(1):71-9. doi: 10.1016/0008-6215(90)80006-o.
O-alpha-D-Glucopyranosyl-(1----6)-O-beta-D-glucopyranosyl-(1----6)-1-N- [L-aspart-1-oyl-(L-proline)-4-oyl]-alpha- and -beta-D-glucopyranosylamine have been prepared, as models for a derivative possibly present in the glomerular basement membrane of rats, by condensation of the corresponding D-glucosyl-dipeptide derivatives with 2,3,4,2',3',4',6'-hepta-O-acetyl-alpha-D-isomaltopyranosyl bromide in the presence of mercuric cyanide, followed by deprotection of the trisaccharide-dipeptide derivatives.
已制备出O-α-D-吡喃葡萄糖基-(1→6)-O-β-D-吡喃葡萄糖基-(1→6)-1-N-[L-天冬氨酰-(L-脯氨酸)-4-酰基]-α-和-β-D-吡喃葡萄糖胺，作为可能存在于大鼠肾小球基底膜中的一种衍生物的模型，方法是在氰化汞存在下，使相应的D-葡萄糖基-二肽衍生物与2,3,4,2',3',4',6'-七-O-乙酰基-α-D-异麦芽糖基溴缩合，随后对三糖-二肽衍生物进行脱保护。
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