Risk factors for coronary heart disease during 25 years of follow-up. The study of men born in 1913.

We followed 845 50-year-old men initially free of coronary heart disease (CHD) for 25 years. Blood pressure, serum cholesterol and smoking habits were significant and independent risk factors for CHD during the first 15 years of follow-up and for the whole follow-up period. CHD during the last 10 years of follow-up could be predicted by blood pressure, serum cholesterol and triglycerides and also by body mass index, but not by smoking habits in univariate analyses. Only blood pressure was an independent risk factor for CHD during the last 10 years of follow-up in multivariate analysis.