Gottschalk J, Korves M, Skotzek-Konrad B, Goebel S, Cervós-Navarro J
Institute of Neuropathology, Free University of Berlin, Germany.
Clin Neuropathol. 1993 May-Jun;12(3):175-8.
Dysembryoplastic neuroepithelial tumors (DNT) are rare, cortically located neoplasma associated with intractable partial complex seizures. This entity was first described by Daumas-Duport et al. [1988], who also coined the term DNT. In that report, at the time of operation, the patients' ages ranged from 3 to 30 years and the duration of symptoms ranged from 2 to 18 years. In contrast, we observed a histologically comparable tumor in a 75-year-old female with a 60 year epilepsy history. Autopsy revealed an 8 mm large tumor in the right hippocampus. In view of the extremely prolonged course of the patient's symptoms and the complete lack of excessive cell proliferation, the differentiation of a genuine tumor versus a hamartoma remains equivocal.
胚胎发育不良性神经上皮肿瘤（DNT）是一种罕见的、位于皮质的肿瘤，与难治性部分性癫痫发作有关。该实体最初由Daumas-Duport等人于1988年描述，他们还创造了DNT这个术语。在那份报告中，手术时患者年龄在3至30岁之间，症状持续时间在2至18年之间。相比之下，我们在一名有60年癫痫病史的75岁女性中观察到了一种组织学上类似的肿瘤。尸检发现右侧海马体有一个8毫米大的肿瘤。鉴于患者症状的病程极长且完全缺乏过度的细胞增殖，真正的肿瘤与错构瘤的鉴别仍不明确。
