Martínez J, Mendoza J
Chemotherapy. 1977;23 Suppl 1:275-80. doi: 10.1159/000222060.
A study was made of the activity of fosfomycin in vitro and in vivo against different bacterial strains localized in the urinary tract of paraplegic patients hospitalized for their rehabilitation in our Hospital. A total of 22 patients were studied and 24 treatments were carried out. A total of 33 organisms were isolated in the initial cultures. In all patients, the pattern of administration of the antibiotic was 4 g/day intramuscularly during 8 days. From the bacteriological standpoint, the results were excellent, although there was no question of clinical results due to the special circumstances of these patients. A sterilization of the urocultures was achieved in 20 of the 24 cases treated. No signs of intolerance or toxicity were observed in any of the patients upon administering the antibiotic.
对磷霉素在体外和体内针对我院因康复住院的截瘫患者尿道中不同细菌菌株的活性进行了一项研究。共研究了22例患者，进行了24次治疗。初始培养中共分离出33种微生物。所有患者中，抗生素的给药方式为8天内每天4克肌肉注射。从细菌学角度来看，结果非常好，不过由于这些患者的特殊情况，未涉及临床结果。24例接受治疗的病例中有20例实现了尿培养灭菌。在给予抗生素时，未在任何患者中观察到不耐受或毒性迹象。
