Thoumsin H, Aghayan M, Lambotte R
Department of Gynecology and Obstetrics, University Hospital, Liège, Belgium.
Infection. 1990;18 Suppl 2:S94-7. doi: 10.1007/BF01643435.
Pregnancy induces anatomical and physiological changes in the urinary tract. In this condition a bacteriuria, even asymptomatic, may lead more frequently to pyelonephritis. Asymptomatic bacteriuria in pregnant women has therefore got to be treated. According to recent studies, long course antibiotherapy did not prove to be more effective than a single-dose one in the case of non-complicated bacteriuria. Moreover, the maternal and foetal toxicity should be reduced in the latter regimen. In this paper we present the preliminary results of our study comparing a single-dose treatment by fosfomycin trometamol (3 g) and nitrofurantoin (200 mg per day during a week).
妊娠会引起泌尿系统的解剖学和生理学变化。在这种情况下，即使是无症状菌尿也可能更频繁地导致肾盂肾炎。因此，孕妇的无症状菌尿必须得到治疗。根据最近的研究，在非复杂性菌尿的情况下，长疗程抗菌疗法并不比单剂量疗法更有效。此外，后一种疗法应降低母体和胎儿的毒性。在本文中，我们展示了我们的研究初步结果，该研究比较了磷霉素氨丁三醇单剂量治疗（3克）和呋喃妥因（一周内每天200毫克）。
