Kempner E S
Laboratory of Physical Biology National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
FEBS Lett. 1993 Jul 12;326(1-3):4-10. doi: 10.1016/0014-5793(93)81749-p.
Two classes of protein whose structure is modified by small ligands are reviewed. Proteins of one group contain two massive domains joined by a flexible link; in response to small molecules, the two lobes approach and enclose the ligand. In the other, a short segment of amino acids moves as a flexible loop over the ligand which often is trapped in a non-aqueous environment. Biochemical reaction rates are altered dramatically by these movements.
本文综述了两类结构因小分子配体而发生改变的蛋白质。一类蛋白质包含两个由柔性连接键相连的巨大结构域；在小分子的作用下，这两个叶状结构靠近并包围配体。另一类蛋白质中，一小段氨基酸以柔性环的形式在配体上方移动，配体通常被困在非水环境中。这些移动会显著改变生化反应速率。
