Gregory R, Mills K, Donaghy M
Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK.
J Neurol. 1993 May;240(5):309-14. doi: 10.1007/BF00838169.
Sensory nerve function was determined in 19 patients with amyotrophic lateral sclerosis (ALS), using a battery of clinical and neurophysiological tests. This assessment was repeated on 12 patients after intervals of 6-18 months. Twelve controls were also studied. In the ALS group, only 2 patients had noticed mild sensory symptoms and none had sensory signs. Between successive studies the vibration thresholds increased, but not to a significant degree. ALS patients showed a significant fall in amplitude of the sensory nerve action potentials in the median, radial, and sural nerves (P < 0.04); sensory nerve conduction velocity did not alter. The median nerve somatosensory evoked potential N19 latency showed a highly significant increase (P < 0.008). Significant subclinical deterioration in sensory nerve function occurs in ALS, and parallels the progressive motor decline. Neuronal degeneration in ALS is not restricted to motor neurons.
采用一系列临床和神经生理学测试，对19例肌萎缩侧索硬化症（ALS）患者的感觉神经功能进行了测定。12例患者在6 - 18个月的间隔后重复了此项评估。还对12名对照者进行了研究。在ALS组中，只有2例患者注意到轻微的感觉症状，且无一例有感觉体征。在连续研究之间，振动阈值有所增加，但幅度不显著。ALS患者正中神经、桡神经和腓肠神经的感觉神经动作电位幅度显著下降（P < 0.04）；感觉神经传导速度未改变。正中神经体感诱发电位N19潜伏期显著延长（P < 0.008）。ALS患者存在明显的感觉神经功能亚临床恶化，且与进行性运动功能衰退平行。ALS中的神经元变性并不局限于运动神经元。
