Mulder D W, Bushek W, Spring E, Karnes J, Dyck P J
Neurology. 1983 Dec;33(12):1625-7. doi: 10.1212/wnl.33.12.1625.
Cutaneous touch-pressure, vibration, and thermal cooling detection thresholds were estimated on the skin of one foot for 80 patients with motor neuron disease (MND) and compared with that of more than 300 site, age, and sex-matched healthy controls. Fourteen of the patients had elevated thresholds (greater than or equal to 95th percentile): 7 showed elevated thresholds of sensitive points, 5 an increased number of insensitive grid points, and 2 a combination of these criteria. Therefore, raised vibration thresholds occur more frequently in MND patients than in controls (p less than 0.001). A detection threshold abnormality was not demonstrated for touch-pressure or for thermal cooling. These results are in keeping with the demonstrated increased cutaneous myelinated fiber degeneration in this condition and with evidence of sensory neural system involvement at postmortem examination. Although motor neurons are selectively vulnerable in MND, afferent neurons may also be affected, albeit less frequently and/or to a lesser degree.
对80例运动神经元病（MND）患者单足皮肤的触觉压力、振动及冷觉检测阈值进行了评估，并与300多名年龄、性别匹配的健康对照者进行比较。14例患者阈值升高（大于或等于第95百分位数）：7例敏感点阈值升高，5例无感觉网格点数量增加，2例符合上述两种标准。因此，MND患者振动阈值升高的发生率高于对照组（p<0.001）。触觉压力和冷觉检测阈值未显示异常。这些结果与已证实在该疾病中皮肤有髓纤维变性增加以及尸检时感觉神经系统受累的证据相符。虽然运动神经元在MND中易受选择性损害，但传入神经元也可能受到影响，尽管频率较低和/或程度较轻。
