Gearhart J P, Peppas D S, Jeffs R D
Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
J Urol. 1993 Aug;150(2 Pt 2):627-30. doi: 10.1016/s0022-5347(17)35566-0.
We reviewed the cases of the exstrophy/epispadias complex treated at our institution between July 1976 and April 1992. A total of 78 patients was identified who had paraexstrophy skin flaps used in the bladder closure, of whom 31 (40%) had a complication as a result of the flaps. The main complication encountered was a urethral stricture where the paraexstrophy skin flaps joined the urethral plate area. Multiple maneuvers were undertaken to correct these problems, including direct vision internal urethrotomy (12 cases), multiple urethral dilations (4), open revision (3) and full thickness skin grafts (5). Seven patients had such a complex stricture situation that they required either continent urinary diversion (5), colon conduit diversion (1) or cutaneous ureterostomy (1), the latter 2 patients having undergone vesicostomy elsewhere before referral. Of the remaining 24 patients who did not undergo a diversionary procedure 12 have undergone an epispadias repair and bladder neck reconstruction, 7 underwent an epispadias repair and 5 await further treatment. Freedom from complications in the initial closure of exstrophy significantly improves the chances of successful reconstruction. The avoidance of problems leading to obstruction, infection, hydronephrosis and reflux nephropathy will provide better kidneys regardless of bladder suitability for function or augmentation. Our use of paraexstrophy flaps has decreased but when they are required, special care in design, placement and followup is advised to avoid complicating strictures and their sequelae.
我们回顾了1976年7月至1992年4月间在本机构接受治疗的膀胱外翻/尿道上裂综合征病例。共确定了78例在膀胱闭合术中使用了膀胱外翻旁皮瓣的患者,其中31例(40%)因皮瓣出现了并发症。遇到的主要并发症是在膀胱外翻旁皮瓣与尿道板区域连接处出现尿道狭窄。采取了多种措施来纠正这些问题,包括直视下内尿道切开术(12例)、多次尿道扩张(4例)、开放修复(3例)和全厚皮片移植(5例)。7例患者的狭窄情况非常复杂,需要进行可控性尿流改道(5例)、结肠导管改道(1例)或皮肤输尿管造口术(1例),后2例患者在转诊前曾在其他地方接受过膀胱造瘘术。在其余24例未接受改道手术的患者中,12例接受了尿道上裂修复和膀胱颈重建,7例接受了尿道上裂修复,5例等待进一步治疗。膀胱外翻一期闭合时避免并发症可显著提高成功重建的几率。避免导致梗阻、感染、肾积水和反流性肾病的问题,无论膀胱功能是否适合或是否需要扩大,都能使肾脏状况更好。我们使用膀胱外翻旁皮瓣的情况有所减少,但当需要使用时,建议在设计、放置和随访过程中特别小心,以避免出现复杂的狭窄及其后遗症。