Mittelviefhaus H
Universitäts-Augenklinik Freiburg.
Kinderarztl Prax. 1993 May;61(3):90-6.
Ocular toxoplasmosis is a frequent cause of ocular inflammation which threatens central visual acuity. New concepts of treatment are important alternatives for the well known therapy with pyrimethamine and sulphadiazine. They cause less side effects and result in better compliance. Up to know prospective randomized trials are still missing although they might prove the value of medical treatment in ocular toxoplasmosis. Nevertheless it is generally accepted that ocular toxoplasmosis should be treated when central visual function is threatened. Treatment strategy is influenced by general symptoms, especially in children and immunocompromised patients. In this paper opportunities for treatment are discussed. Relevant microbiological, immunological and epidemiological fundamentals are mentioned as well as serological tests.
眼部弓形虫病是威胁中心视力的眼部炎症的常见病因。治疗的新理念是已知的乙胺嘧啶和磺胺嘧啶疗法的重要替代方案。它们副作用较小，依从性更好。尽管前瞻性随机试验可能会证明药物治疗在眼部弓形虫病中的价值，但截至目前此类试验仍缺失。然而，人们普遍认为，当中心视觉功能受到威胁时，应治疗眼部弓形虫病。治疗策略受一般症状的影响，尤其是在儿童和免疫功能低下的患者中。本文讨论了治疗的机会。还提及了相关的微生物学、免疫学和流行病学基础知识以及血清学检测。
