MacLean K I, Littleton J M
Eur J Pharmacol. 1977 Jan 21;41(2):171-82. doi: 10.1016/0014-2999(77)90206-0.
In rats housed normally (aggregated, food and water ad lib) for fourteen days delta8-tetrahydrocannabinol (THC) produced mild sedation and minimal hypothermia. An increase in noradrenaline synthesis was observed, but brain dopamine metabolism was unchanged. In rats removed from this 'normal' environment to conditions of isolation and food deprivation for 24 h THC produced immobility, marked hyper-reactivity, and hypothermia. Brain noradrenaline metabolism was unchanged by THC under these conditions, but significant changes in striatal dopamine metabolism were observed. These changes are consistent with increased dopamine reuptake in striatum produced by this combination of THC and novel environment. It is suggested that some of the behavioural effects of cannabis administered under stressful conditions may be related to alterations in striatal dopamine metabolism.
正常饲养（群居，自由获取食物和水）14天的大鼠，δ8 - 四氢大麻酚（THC）会产生轻度镇静作用和轻微体温过低。观察到去甲肾上腺素合成增加，但脑内多巴胺代谢未改变。将大鼠从这种“正常”环境转移到隔离且食物剥夺24小时的条件下，THC会导致其不动、明显的过度反应和体温过低。在这些条件下，THC并未改变脑内去甲肾上腺素代谢，但观察到纹状体多巴胺代谢有显著变化。这些变化与THC和新环境的这种组合所导致的纹状体多巴胺再摄取增加相一致。有人提出，在应激条件下服用大麻的一些行为效应可能与纹状体多巴胺代谢的改变有关。
