δ9-四氢大麻酚诱导的大鼠内源性下丘脑前列腺素水平的改变。
Alteration in the level of endogenous hypothalamic prostaglandins induced by delta 9-tetrahydrocannabinol in the rat.
作者信息
Coupar I M, Taylor D A
出版信息
Br J Pharmacol. 1982 May;76(1):115-9. doi: 10.1111/j.1476-5381.1982.tb09196.x.
Abstract
1 Whole brain and regional brain levels of prostaglandin E2 (PGE2)-like material have been determined following administration of delta 9-tetrahydrocannabinol (delta 9 -THC) in rats. 2 Intravenous administration of delta 9-THC 2 mg/kg, resulted in marked behavioural changes and hypothermia. The behavioural changes consisted mainly of catatonia (most apparent at 30 min after administration of delta 9-THC), followed by sedation (most evident at 60 min). Hypothermia was marked from 30 min after administration of delta 9-THC. 3 delta 9-THC did not after the whole brain levels of PGE2-like material 30, 60 or 120 min after administration. 4 delta 9-THC did not alter the levels of PGE2-like material in the medulla oblongata/pons, midbrain, cortex and cerebellum, 30 min after administration. However, there was a significant reduction of PGE2-like material in the hypothalamus, 30 min after delta 9-THC. 5 It is suggested that the delta 9-THC-induced decrease in hypothalamic PGE2-like material may contribute to the hypothermia observed following delta 9-THC administration.
摘要
- 在给大鼠注射Δ⁹-四氢大麻酚（Δ⁹-THC）后，已测定了全脑和脑区中前列腺素E2（PGE2）样物质的水平。2. 静脉注射2mg/kg的Δ⁹-THC会导致明显的行为变化和体温过低。行为变化主要包括紧张症（在注射Δ⁹-THC后30分钟最为明显），随后是镇静（在60分钟时最为明显）。注射Δ⁹-THC后30分钟开始出现明显的体温过低。3. 注射后30、60或120分钟，Δ⁹-THC并未改变全脑中PGE2样物质的水平。4. 注射后30分钟，Δ⁹-THC并未改变延髓/脑桥、中脑、皮层和小脑中PGE2样物质的水平。然而，注射Δ⁹-THC后30分钟，下丘脑中PGE2样物质显著减少。5. 有人提出，Δ⁹-THC引起的下丘脑PGE2样物质减少可能导致了注射Δ⁹-THC后出现的体温过低。
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