Funaki N, Arii S, Adachi Y, Higashituji H, Tanaka J, Imamura M
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Life Sci. 1993;53(4):323-31. doi: 10.1016/0024-3205(93)90751-n.
We analyzed PGE2 production in primary-cultured human hepatic macrophages (HHM phi) and peripheral monocytes (MO) from patients with and without liver cirrhosis, and correlated PGE2 production with the patients' liver function. Serum choline esterase (ChE) levels were used as an indicator of liver function. PGE2 production in both HHM phi and MO from cirrhotic patients was significantly lower than in HHM phi and MO from non-cirrhotic patients. PGE2 production in cirrhotic HHM phi was inversely correlated with ChE levels, whereas PGE2 production in cirrhotic MO showed no obvious correlation. In conclusion, both HHM phi and MO might contribute to the pathophysiology of liver cirrhosis via attenuated PGE2 production. Furthermore, HHM phi activity appears to be more strongly affected by the chronic pathological changes observed in the cirrhotic liver.
我们分析了原发性培养的人肝巨噬细胞（HHM phi）和来自肝硬化患者及非肝硬化患者的外周血单核细胞（MO）中前列腺素E2（PGE2）的产生情况，并将PGE2的产生与患者的肝功能进行关联。血清胆碱酯酶（ChE）水平被用作肝功能的指标。肝硬化患者的HHM phi和MO中PGE2的产生均显著低于非肝硬化患者的HHM phi和MO。肝硬化HHM phi中PGE2的产生与ChE水平呈负相关，而肝硬化MO中PGE2的产生无明显相关性。总之，HHM phi和MO都可能通过PGE2产生减少而参与肝硬化的病理生理过程。此外，HHM phi的活性似乎受肝硬化肝脏中观察到的慢性病理变化影响更大。
