Heffez D S, Aryanpur J, Rotellini N A, Hutchins G M, Freeman J M
Chicago Institute of Neurosurgery and Neuroresearch, Illinois.
Neurosurgery. 1993 Jun;32(6):1005-10. doi: 10.1227/00006123-199306000-00021.
The paralysis seen in children with myelomeningocele has been attributed to congenital myelodysplasia. Clinical and pathological data, however, suggest that the paralysis may be due in part to a spinal cord injury caused by exposure of the neural tube to the intrauterine environment. This possibility has been supported by experimental data obtained using a fetal rat model of surgically created dysraphism. In this paper, we report the results of intrauterine treatment of experimental dysraphism in the fetal rat and the fetal pig. These studies confirm our earlier findings and suggest that both physical trauma and toxic injury may contribute to the spinal cord injury.
脊髓脊膜膨出患儿出现的瘫痪一直被归因于先天性脊髓发育异常。然而，临床和病理数据表明，这种瘫痪可能部分是由于神经管暴露于子宫内环境而导致的脊髓损伤。使用手术造成脊柱裂的胎鼠模型获得的实验数据支持了这一可能性。在本文中，我们报告了对胎鼠和胎猪实验性脊柱裂进行宫内治疗的结果。这些研究证实了我们早期的发现，并表明物理创伤和毒性损伤都可能导致脊髓损伤。
