Girolami A
Folia Haematol Int Mag Klin Morphol Blutforsch. 1978;105(4):523-9.
Coumarin drugs or vitamin K absence cause a decrease of factor II, VII, IX and X activities and the appearance of pre-factors into the circulation. Such pre-factors have been postulated to inhibit thrombin conversion. The current of research on the alleged activity of such "inhibitors" is taken into consideration. Thrombotest discrepancy, mixing experiments etc.) speak against the inhibitor theory. So far the only sure demonstration of the presence of coumarin induced pre-factors has been obtained by immunological means. However, this does not say anything about their biological activity. These pre-factors could well be "inert" as far as clotting is concerned. Until new, unequivocal data on the subject will be available, any method or technique claiming to be able to detect or monitor the "inhibitory" effect should be accepted with extreme caution. Too many unjustified views have been put forward in recent years.
香豆素类药物或维生素K缺乏会导致凝血因子II、VII、IX和X活性降低，并使前体因子进入血液循环。据推测，此类前体因子可抑制凝血酶转化。本文考虑了关于此类“抑制剂”所谓活性的研究进展。凝血酶原时间测定差异、混合试验等均不支持抑制剂理论。到目前为止，通过免疫学方法是唯一能确切证明香豆素诱导的前体因子存在的方法。然而，这并不能说明它们的生物学活性。就凝血而言，这些前体因子很可能是“无活性的”。在获得关于该主题的新的确切数据之前，任何声称能够检测或监测“抑制”作用的方法或技术都应极其谨慎地接受。近年来提出了太多不合理的观点。
