Girolami A, Fabris F, dal Bo Zanon R, Cappellato G
Folia Haematol Int Mag Klin Morphol Blutforsch. 1977;104(5):670-6.
The apparent "inhibition" found in coumarin plasma by means of the dilution curve system seems to decrease with the increase of anticoagulation. Three groups of anticoagulated patients with a P/N prothrombin time ratio of less than 1.8, between 1.8 and 2.3 and over 2.3, showed an "inhibition" of 1.6, 1.1 and 0.9 conventional units, respectively. An inverse correlation was found to exist between Thrombotest clotting times, P/N ratio, antigen/activity ratios on one side and inhibition units on the other side. These findings do not confirm the presence of "inhibitors" in coumarin treated patients.
通过稀释曲线系统在香豆素血浆中发现的明显“抑制作用”似乎随着抗凝作用的增强而降低。三组凝血酶原时间P/N比值小于1.8、在1.8至2.3之间以及大于2.3的抗凝患者，其“抑制作用”分别为1.6、1.1和0.9个传统单位。发现凝血试验凝血时间、P/N比值、抗原/活性比值与抑制单位之间存在负相关。这些发现并未证实香豆素治疗患者中存在“抑制剂”。
