曼氏血吸虫紫外线减毒尾蚴在啮齿动物宿主中的免疫潜力。
Immunizing potential of ultraviolet-attenuated cercariae of Schistosoma mansoni in rodent hosts.
作者信息
Kamiya H, Ozaki T, Nakayama H, Inaba T
机构信息
Department of Parasitology, Hirosaki University School of Medicine, Japan.
出版信息
Parasitol Res. 1993;79(4):293-6. doi: 10.1007/BF00932184.
Schistosoma mansoni cercariae attenuated with ultraviolet (UV) irradiation (254 nm) at a dose of 18 mJ/cm2 induced partial resistance against a homologous challenge in male ICR mice and male Hartley guinea pigs. The reduction in the adult worm burden was 51% and 37% +/- 13%, respectively. On the other hand, male and female Mongolian gerbils (Meriones unguiculatus) vaccinated with UV-attenuated cercariae exhibited marginal resistance (13% +/- 9% and 22% +/- 10%, respectively). This raises the possibility that gerbils might have an unknown immune-characteristic nature. The usefulness of UV-attenuated cercariae is discussed with respect to the control of the disease.
用紫外线（UV）以18 mJ/cm2的剂量进行照射（254 nm）减毒的曼氏血吸虫尾蚴，可诱导雄性ICR小鼠和雄性哈特利豚鼠对同源攻击产生部分抗性。成虫虫负荷的降低分别为51%和37%±13%。另一方面，用紫外线减毒尾蚴接种的雄性和雌性蒙古沙鼠（长爪沙鼠）表现出微弱的抗性（分别为13%±9%和22%±10%）。这增加了沙鼠可能具有未知免疫特性的可能性。本文讨论了紫外线减毒尾蚴在疾病控制方面的实用性。
Zotero 插件